Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling
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چکیده
منابع مشابه
miR-33-5p Regulates CREB to Induce Morphine State-dependent Memory in Rats: Interaction with µ Opioid Receptor
The aim of the present study was to examine the hypothesis that miR-33-5p attenuates morphine state-dependent (StD) memory via the µ opioid receptor by regulating cyclic AMP response element-binding protein (CREB). The effects of post-training morphine and morphine StD memory and their interaction with pre-test naloxone were evaluated using a single-trial inhibitory avoidance paradigm. Then, th...
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Introduction: The current study aimed at investigating the existence of the cross state-dependent learning between morphine and scopolamine (SCO) in mice by passive avoidance method, pointing to the role of CA1 area. Methods: The effects of pre-training SCO (0.75, 1.5, and 3 μg, Intra-CA1), or morphine (1, 3, and 6 mg/kg, intraperitoneal (i.p.) was evaluated on the retrieval of passiv...
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It has been shown that pre-test systemic administration of morphine was able to reverse memory impairment induced by pre- or post-training morphine in an inhibitory avoidance paradigm. Since the recall of the learned information is possible only if the subject is in the same state as during the encoding phase, this kind of learning is known as state-dependent learning. Several drugs have been d...
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In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5 mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administr...
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ژورنال
عنوان ژورنال: Basic and Clinical Neuroscience Journal
سال: 2020
ISSN: 2228-7442,2008-126X
DOI: 10.32598/bcn.11.4.1482.1